POTENTIAL ANTI-PSEUDOMONAS AERUGINOSA AGENTS PHENAZINES

The amino groups and the lipophilic side chain in polymyxin B have been reported to be responsible for the action against Pseudomonas aeruginosa. Since phenazine derivatives usually exhibited potent bacteriostatic action, we have accordingly prepared a number of phenazinium salts carrying amino groups and an N-alkyl side chain for screening purposes. However, antibacterial tests showed that none of the compounds so prepared was active.