Structural modification of cyclovirobuxine D and their inhibition activity on lipid peroxidation

AimTo search for compounds through structural modification of cyclovirobuxine D, using 20 or 21-aminosteroids as lead compound for the treatment of cerebrovascular diseases with better lipid peroxidation inhibitory activity. MethodsAccording to rational drug design principle, a series of cyclovirobuxine D analogues were prepared, and their bioactivities were tested. ResultsFour new compounds were obtained and confirmed by spectra. ConclusionLipid peroxidation inhibitory effects of cyclovirobuxine D analogues were tested by using TBA method. Some compounds showed better activity than that of cyclovirobuxine D.