Research progress of hypoxia-inducible factor 1 inhibitors against tumors

Hypoxia occurs in chronic and acute vascular diseases and tumor formation.The ability of tumor cells to maintain a balance between an adaptation to hypoxia and cell death is regulated by a familyof transcription factors called hypoxia-inducible factor 1 (HIF-1).Tumor hypoxia mediated by HIF-1 would facilitate the likelihood of resistance to chemotherapy and radiotherapy, proliferation, metastasis and theinvasive potential; all of which culminate in a decrease in patient survival.And HIF-1α subunit decides the activity of HIF-1, which is regulated by oxygen.So understanding the role of HIF in signal pathway, drug resistance mechanism and its feature is crucial for developing novel anticancer therapies.In recent years, more attentions have focused on HIF-1α inhibitors.It is expected that development of more potent and selective HIF inhibitors will provide an effective treatment of cancer and other HIF-related diseases.So we will focus on the biological characteristics and mechanism of HIF-1 to review currently studied HIF-1 inhibitors.