Preliminary exploration of inhibitory activities of Salvia species on PTP1B

An in vitro screening model was applied to test the inhibitory activities of 17 Salvia species on protein tyrosine phosphatase 1B (PTP1B).  Root methanol extracts from wild-collected Salvia species were  analyzed using this model.  Most of the samples tested showed positive activities on human PTP1B.  The   inhibition rates of Salvia crude extracts varied from 9.76% to 100% at 30 μg·mL^-1, with the most convincing  effects coming from Salvia evansiana and Salvia castanea.  HPLC analysis revealed seven components shared by Salvia samples could be related to the inhibitory activities.