THE EFFECTS OF CHLORPROMAZINE ON PENICILLIN THERAPY OF STAPHYLOCOCCAL INFECTION IN MICE

It has been confirmed by the present experiments that chlorpromazine reduced the survival rate of mice infected intraperitonelly with penicillin-resistant Staph. aureus. The therapeutic efficacy of penicillin in the infected mice was also reduced by chlorpromazine. The time of injection of each drug seemed to be also an influencing factor to the reduc- tion of therapeutic efficacy.