STUDIES ON STRUCTURE MODIFICATION OF (+)-PRAERUPTORIN A

AIM In order to look for new active compounds, the structure of (+)-praeruptorin A is modified. METHODS (+)-Praeruptorin A was isolated from the root of Peucedanum praeruptorum, basic hydrolysis of (+)-praeruptorin A and acyled reactions of hydrolysis product of (+)-praeruptorin A were carried out. RESULTS Eighteen compounds were semi-synthesized from (+)-praeruptorin A. CONCLUSION Fourteen compounds (5～18) among them are new compounds. Preliminary bioactivity assay indicated that the new compounds show...