FENG Nian-ping, ZHANG Zheng-xing, AN Deng-kui, HAN Xiu-wen, HUAN Wen-long, WANG Guang-ji. ANALYSIS OF THE METABOLITE OF 7-(4-CHLORBENZYL)-7,8,13,13a-TETRAHYDROBERBERINE IN RABBITJ. Acta Pharmaceutica Sinica, 2001, 36(2): 137-139.
Citation: FENG Nian-ping, ZHANG Zheng-xing, AN Deng-kui, HAN Xiu-wen, HUAN Wen-long, WANG Guang-ji. ANALYSIS OF THE METABOLITE OF 7-(4-CHLORBENZYL)-7,8,13,13a-TETRAHYDROBERBERINE IN RABBITJ. Acta Pharmaceutica Sinica, 2001, 36(2): 137-139.
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ANALYSIS OF THE METABOLITE OF 7-(4-CHLORBENZYL)-7,8,13,13a-TETRAHYDROBERBERINE IN RABBIT

    Abstract
  • AIM　To explore the biotransformation of compound 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine in the rabbit. METHODS　Analyze the rabbit bile sample with HPLC, LC/MS and LC/NMR. RESULTS　A metabolite and unchanged 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine were found in the rabit bile, the metabolite was characterized and its structure was elucidated. CONCLUSION　Compound 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine is metabolized by demethylation at 10-OCH3 position.
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