INHIBITORY EFFECT OF MATRINE ON LIPOPOLYSACCHRIDE INDUCED TUMOR NECROSIS FACTOR AND INTERLEUKIN-6 PRODUCTION FROM RAT KUPFFER CELLS

The effect of matrine on the lipopolysacchride (LPS)-induced tumor necrosis factor and interleukin-6 production from rat Kupffer cell was investigated. Results showed that matrine 125, 250 and 500 mg·L^-1 suppressed TNF and IL-6 production from Cal primed Kupffer cells in the presence of lipopolysacchrides (LPS, 100 μg·L^-1) in a concentration dependent manner. Treatment with matrine 50 and 100 mg·kg^-1 before LPS injection(3.5 mg·kg^-1) markedly decreased mouse serum TNF and IL-6. The results suggest that matrine may have protective effect on LPS-inuced liver injury.