THE SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF C GALACTOSIDES OF FURANOSESQUITERPENES

Four new C-galactosides were obtained by the treatment of 1-O-trifluoroacetyl-2,3,4,6-tetra-O-benzyl-α-D-galactopyranose with 7-methoxy-6-(3-pentenyl)-3,5-dimethylbenzofuran, 7-acetoxy-6-(3-pentenyl)3,5-dimethylbenzofuran and 1,2-dihydrocacalohastin in the presence of Lewis acid. Their structures and compositions were elucidated by elemental analysis and spectroscopic methods. The results of the pharmacological test indicated that the sesquiterpenes are calcium antagonists but their C-galactosides are calcium agonists.