SYNTHESIS AND ANTIOSTEOPOROSIS ACTIVITY OF STEROID-BISPHOSPHONATE COMPOUNDS

Bisphosphonate have boneseeking affinity, some of them are used as drugs for osteoporosis. Steroidal hormones are often used in prevention and treatment of osteoporosis. In order to search for bone-targeted leading compounds with high affinity and low toxicity, seven steroidbisphosphonate compounds were synthesized. These compounds were found to promote bone formation in bone cell culture.