SYNTHESIS AND ANTITUMOR ACTIVITY OF 3 (SUBSTITUTED PHENYL)VINYL INDOLE DERIVATIVES

AIM: A series of 3 (substituted phenyl)vinyl indole derivatives had been synthesized in order to find compounds with antitumor activity by screening in vitro. METHODS: Title compounds were synthesized by Wittig reaction, Wittig Horner reaction and Phase Transfer Wittig reaction. RESULTS: Twenty nine compounds of 3 (substituted phenyl)vinyl indole were synthesized. Five compounds showed different inhibitory effects on HCT 8 and KB and Bel7402 cell lines in vitro, and one compound high activity on immunity. CONCLUSION: Some compounds with high antitumor and immunoincreasing activities were obtained and is worth while for further study.