Li Tun, Liu Dingyuan , Meng Jinxue Zhu Shufang Lu Shengzhang , Gao Xinyu Shen Lianlan , Yang Wenshu, . THE CALCULATION OF PHARMACOKINETIC PARAMETERS OF TETRACYCLINE AND THE FORMULA OF CORRELATION BETWEEN BLOOD LEVEL AND URINARY EXCRETIONJ. Acta Pharmaceutica Sinica, 1981, 16(12): 886-891.
Citation: Li Tun, Liu Dingyuan , Meng Jinxue Zhu Shufang Lu Shengzhang , Gao Xinyu Shen Lianlan , Yang Wenshu, . THE CALCULATION OF PHARMACOKINETIC PARAMETERS OF TETRACYCLINE AND THE FORMULA OF CORRELATION BETWEEN BLOOD LEVEL AND URINARY EXCRETIONJ. Acta Pharmaceutica Sinica, 1981, 16(12): 886-891.
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THE CALCULATION OF PHARMACOKINETIC PARAMETERS OF TETRACYCLINE AND THE FORMULA OF CORRELATION BETWEEN BLOOD LEVEL AND URINARY EXCRETION

    Abstract
  • The pharmacokinetic parameters of tetracycline were calculated by using plasma and urinary data in volunteers reported in a previous article. The formula of correlation between blood level and urinary excretion was suggested. The values of K,clr, Ka, F, Vd, and Ke were 0.06409, 65.67ml/hr 0.70,60.88%, 101 L and 0.039 respectively. The minimun plateau levels of six tablets were calculated from single dose experiment.
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