Active constituents from Aloe arborescens as BACE inhibitors

AimTo seek for new components as BACE inhibitors from Aloe arborescens. Methods The chemical constituents were isolated by chromatographic methods and their structures were elucidated on the basis of spectral analysis. ResultsEight compounds were isolated and their structures identified as 6′-O-isobutyryl aloenin A (1), aloenin A (2), aloe-emodin (3), (E)-2-acetonyl-8-(2′-O-feruloxyl)-β-D-glucopyranosyl-7-methoxy-5-methyl-chromone (4), 7-O-methylaloeresin A (5), babarloin A (6), elgonica-dimer A (7), and elgonica-dimer B (8), separately. ConclusionCompound 1 is a new compound, and compound 4 was isolated from A.arborescens for the first time. Pharmacological tests indicated that 2, 4, 5 and 6 have moderate inhibitory active on BACE.