ACETYLSALVIANOLIC ACID A──A NEW THROMBOXANE SYNTHETASE INHIBITOR

With radio thin layer chromatography and autoradiogram, the effect of acetylsalvianolic acid A (ASAA) on ¹⁴C-arachidonic metabolism by platelets was studied in vitro. ASAA was found to enhance the formation of PGE-2 and PGF_2α remarkably while inhibiting the formation of TXB₂. However, it showed no effect on the formation of 12-HETE and arachidonic utility rate. Therefore, we deduce that ASAA may be a thromboxane synthetase inhibitor.