BIOAVAILABILITY OF A CONTROLLED-RELEASE SUSPENSION OF PHENYLPROPANOLAMINE IN HEALTHY VOLUNTEERS

A high- performance liquid chromatographic analysis ofphenylpropanolamine (PPA) in human plasma is presented. Using direct UV detectionthe method is sufficiently sensitive to 25 ng/ml for PPA. Single-dose pharmacokineticsof PPA in 10 healthy volunteers taking controlled release suspension (C) or tablet (T),each containing 150 mg PPA was compared. The study described here has shown thatthe (C) AUC_0～∞/(T) AUC_0～∞ = 1.02(P>0.4). The controlled-release product ofPPA is equivalent to PPA tablet.