SYNTHESIS OF S-9-(2,3-DIHYDROXYPROPYL)ADENINE (DHPA) ANALOGS AND THEIR INHIBITION OF S-ADENOSYL-L-HOMOCYSTEINE (SAH) HYDROLASE

In order to search for new antiviral agents with high potency and low toxicity, eleven new acyclonucleosides were synthesized. Nucleic acid bases were condensed with 3-chloro-2-methylpropene to give 5～8a.b, which were oxidized by N-methylmorpholine N-oxide in the presence of OsO₄ to give vicinal dihydroxy acyclonucleosides 1～4a.b. Four DHPA analogs have been tested for the inhibitory activities on s adenosyl L homocysteine hydrolase (SAH). Only compound 1 showed some enzyme inhibitory effect with IC 50 of 1.1 mmol·L^-1.