STUDIES ON ANTITUMOR DRUGS——I.SCREENING OF 207 COMPOUNDS ON TRANSPLANTABLE TUMORS IN MICE AND RATS

The screening data on the antitumor activity of 207 compds, were reported. Most of the effective compds, were nitrogen mustard derivatives, among which M₂ (N-formylsarcolysine), M₃ (N-acetylsarcolysine), M₄ (N-formylsarcolysine phenylalanine), M₅ (Glutamylsarcolysine), M₉ (Ethyl-α-nitro-β-di-(2-chloroethyl) amino caproate), M₁₀ (Ethyl-α-nitro-β-di-(2-chloroethyl)amino-β-(p-dimethylaminophenyl)-propionate) were most potent. Among these, M₂ (N-formylsarcolysine) and M₁ (N-formylsarcolysine phenylalanine)have been recommended for clinical trials.