Modulating drug loading and release profile of β-cyclodextrin polymers by means of cross-linked degree

The purpose of the present study is to use β-cyclodextrin polymers (β-CDP) with different cross-linked degree (CLD) to form inclusion complexes with ibuprofen and examine the effects of structural and compositional factors of β-CDP on its drug loading and release behaviors.  A series of β-CDP with different CLD were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and ¹³C NMR spectrum.  The β-CDP was systemically characterized for the relation between the CLD of β-CDP and the drug loading and release as well.  The results of FT-IR and ¹³C NMR showed that similar peak-shaped vibration of β-CDP and β-CD implies that the polymer keeps the original characteristic structure of β-CD.  The CLD of the β-CDP played a critical role in the drug loading and release, increasing the CLD resulted in reduction of drug loading, but increase in drug release.