ARTIFICIAL RECONSTITUTED PULMONAY SURFACTANT USED FOR PREVENTION AND TREATMENT OF ADULT RESPIRATORY DISTRESS SYNDROME Ⅲ.PREVENTION IN ANIMAL MODEL

Based on optimizing the formulations of artificial reconstituted pulmonary surfactant (APS) used for the prevention and treatment of adult respiratory distress syndrome (ARDS) by a surface chemical method, a quartz lung animal model to obtain active alveolar macrophages (AMs) was established, using a bioluminesence technique to optimize APS’s formulation according to the free-radical-scavenging abilities of APS. An optimal formulation was obtained, which showed good surface properties and free radical scavenging abilities. The APS preparation will be used in ARDS animal model test.