SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME NEW 3-METHYL-5-NITROFURA N DERIVATIVES

Nineteen new compounds of 3-methyl-5-nitrofuran derivatives have been synthesized and their biological activities studied.3-Methyl-nitrofurans were synthesized from 3-methyl-2-furaldehyde obtained from methyl 3-methyl-2-furoate by McFadyen process, and the aldehyde condensed with malonic acid to form β-(3-methyl-2-furan) acrylic acid by Knoevenagel reaction. Nitration of the latter compound provided the key intermediate of β-(3-methyl-5-nitro-2-furan) acrylic acid, which was converted to compounds Ⅰ. The starting material for preparing compounds Ⅱ was 3-methyl-5-nitro-2-furaldehyde oxime obtained by nitration of 3-methyl-2-furaldehyde oxime.The biological activities of these compounds will be reported elsewhere.