SYNTHESIS AND ANALGESIC ACTIVITY OF THE DERIVA TIVES OF 3-METHYL FENTANYL

Six analogues of 1-substituted-3-methylfentanyl were synthesized. All of them are liquid compounds. Preliminary pharmacological results sliowed that some compounds of 1-β-substituted vinylethyl-3-methyl derivatives of fentanyl have strong analgesic activity with typical morphine-like action.Structure-activity relationships are briefly discussed.