SYNTHESIS AND CEREBRAL VASODILATING EFFECTS OF TETRAHYDRO-PYRIDO 1,2-a INDOLE DERIVATIVES

Aseries of 2-substituted-6-oxo -10 -2-(N- substituted)carbamoyl ethyl -6,7,8,9-tetrahydro-pyrido1,2 -a indole compounds were synthesized for studying the relation between structures and cerebrovascular activities. The structures of compounds synthesized were confirmed by means of ¹HNMR, M S, IR, UV and elemental analysis.Preliminary pharmacological experiments showed that all these new compounds were effective for cerebral vasodilation. Compound I₇ was the best of all. The β- diethylaminoethylamine moiety seems to be better than β- dimethylaminoethylamine.