SYNTHESIS AND ANTITUMOR ACTIVITIES OF 4-ACYLAMIDO-4-DEOXY-4′-DEMETHYLEPIPODOPHYLLOTOXIN ANALOGUES

Twenty four 4-acylamidc-4-deoxy-4'-demethylepipodophyllotoxins were synthesized by acylation of 4-amino-4-deoxy-4'-demethylepipodophyllotoxin by means of usual methods, and screened in vitro. This type of compounds showed strong antitumor activities, most of them are superior to etoposide in the inhibition against L₁₂₁₀ and KB cells.