Non-nucleoside reverse transcriptase inhibitors (Part 18): Synthesis and anti-HIV activity of 4-allylamino or 4-azido substituted diaryltriazines

Eight new diaryltriazine derivatives containing 4-allylamino and 4-azido substitutes guided by molecular docking have been designed and synthesized based on our previous work.  The evaluation of HIV  inhibitory activity demonstrated that all compounds were potent against HIV-1 replication.  The most active compound 7c exhibited activity against HIV-1 (IC₅₀ = 0.034 μmol×L^-1, SI = 6 475) and the double mutant strain (IC₅₀ = 9.39 μmol×L^-1) in the micromolar range, which was more potent than nevirapine.