STUDIES ON THE CHEMICAL CONSTITUENTS OFGONIOTHALAMUS GRIFFITHII HOOK.F.ET THOMS

AIM: To study the chemical composition in the bark of Goniothalamus griffithii Hook.f.et Thoms. METHODS: Various chromatographic techniques and structural elucidation methods were used to separate and purify the constituents. Their physical and chemical properties and spectral data were measued. RESULTS: Five compounds were isolated from the bark of Goniothalamus griffithii. They were identified as: 5,7-dihydroxyflavanone (I); 5,6-2H-6-styryl-2-pyrone (II); (5R,6S,7R,8R)-7-hydroxy-8-phenyl-tetrahydrofuro［3,2-b］pyran-2-one (III); (6R,7R,8R)-6-(7,8-dihydroxyphenylethyl)-5,6-2H-pyran-2-one (IV); (4S,5R,6S,7S,8R)-6-hydroxy-7-(α-acetoxybenzyl)-tetrahydrofuro［3,2-b］furan-2-one (V). CONCLUSION: Compound V is a new compound. Compound II and III were obtained from this plant for the first time. The pharmacological experiments indicated that Sub II～V had the acti-cancer activity.