SYNTHESIS AND BACTERIOSTATIC ACTIVITY OF NEW THIOSEMICARBAZONE DERIVATIVES-AMINO MERCAPTOTRIAZOLE SCHIFF BASES

4-amino-3-(furan-2)-5-mercapto-1,2, 4-triazole (Ia) and its ten Schiff basesderived from Ia with different aldehydes were synthesized. All the compounds were screened for activi-ty against seven bacteria and three fungi. Most compounds were found to possess different inhibitioneffect on some bacteria and fungi. The azomethine group of Schiff bases is the active functional groupand the substituted groups on the phenyl ring had definite effect on the bacteriostatic and fungistaticactivities. 4- (5-Nitrofurfurylideneamino) -3- (furan-2) -5- mercapto-1,2, 4-triazole (Ik) showed themost powerful antibacterial activity and broad antibacterial spectrum, while 4-salicylideneamino-3-(fu-ran-2)-5-mercapto-1,2,4-triazole possessed strong activity against fungi.