STUDY ON PHARMACOKINETICS OF MITOXANTRONE POLYCYANOACRYLATE NANOPARTICLES FREEZE-DRIED INFECTION BY HPLC COLUMN SWITCHING TECHNIQUE

The drug concentration -time curves of mitoxantrone polycyanoacrylate nanoparticles fteeze-dried injection(DHAQ-PBCA- NP-FDln ) and mitoxantrone solution injection(DHAQ-Sln)in rabbit blood were determined by HPLC column switching technique,and thedifference between the DHAQ-PBCA-NP-FDln and DHAQ -sIn in vivo was observed.The pharma-cokinetic parameters of DHAQ-PBCA-NP-FDln and DHAQ-SIn were presented by statistical moment.The results showed that the MRT and T_1/2 of DHAQ-PBCA-NP-FDIn were 2.15times longer thanthat of DHAQ-SIn,and the Vss was 4.81 times bigger than that of DHAQ-SIn,This indieates thatDHAQ-PBCA-NP-FDln has targeting and prolonging effect on the action in vivo.