STUDIES ON ANTINEOPLASTIC ACTION OF INDIRUBIN DERIVATIVES AND ANALOGUES AND THEIR STRUCTUREACTIIVITY RELATIONSHIPS

Twenty-four indirubin derivatives or analogues have been subjected to experimental antitumor tests. Preliminary results revealed that 13 compounds showed marked inhibitory action against Walker 256 in rats with a tumor weight inhibition of 29⁶7%. Among them compounds 3,4,12,14 and 22 exhibited higher activity than indirubin, especially compounds 3 and 22. The structure-activity relationship of this series of indirubin derivatives and its analogues is discussed.