CHEN Wen-Bin, WANG Bao-Jun, CHEN Bao-Zhen, ZHANG Li-Zhu, YAN Min , LEI Xing-Han, . CHEMOTHERAPEUTIC STUDIES ON SCHISTOSOMIASIS ⅩⅪⅤ. SYNTHESIS FOR DERIVATIVES OF 5-2-(5-NITRO-FURYI-2)-1-SUBSTITUTED VINYL-1, 3, 4-OXADIAZOL-2-ONE AND ITS 1, 3, 4-OXADIAZOLJ. Acta Pharmaceutica Sinica, 1986, 21(10): 761-766.
Citation: CHEN Wen-Bin, WANG Bao-Jun, CHEN Bao-Zhen, ZHANG Li-Zhu, YAN Min , LEI Xing-Han, . CHEMOTHERAPEUTIC STUDIES ON SCHISTOSOMIASIS ⅩⅪⅤ. SYNTHESIS FOR DERIVATIVES OF 5-2-(5-NITRO-FURYI-2)-1-SUBSTITUTED VINYL-1, 3, 4-OXADIAZOL-2-ONE AND ITS 1, 3, 4-OXADIAZOLJ. Acta Pharmaceutica Sinica, 1986, 21(10): 761-766.
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CHEMOTHERAPEUTIC STUDIES ON SCHISTOSOMIASIS ⅩⅪⅤ. SYNTHESIS FOR DERIVATIVES OF 5-2-(5-NITRO-FURYI-2)-1-SUBSTITUTED VINYL-1, 3, 4-OXADIAZOL-2-ONE AND ITS 1, 3, 4-OXADIAZOL

    Abstract
  • Forty-four compounds of nitrofuranvinyl-1,3,4-oxadiazol-2-one and its 1,3,4-oxadiazole have been synthesized. The key intermediate, α-substituted 5-nitro-2-furylacryloylhydrazine, was prepared by known method and it reacted subsequently with phosgen or bromocyanogen to form the corresponding 1,3,4-oxadiazolone of compound Ⅰ and Ⅱ respectively.
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