LQ Zhang, EP Bian, Y Wang. SIDE CHAIN CLEAVAGE OF STEROLS BY MYCOBACTERIUM SP.M12J. Acta Pharmaceutica Sinica, 1992, 27(12): 903-907.
Citation: LQ Zhang, EP Bian, Y Wang. SIDE CHAIN CLEAVAGE OF STEROLS BY MYCOBACTERIUM SP.M12J. Acta Pharmaceutica Sinica, 1992, 27(12): 903-907.
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SIDE CHAIN CLEAVAGE OF STEROLS BY MYCOBACTERIUM SP.M12

    Abstract
  • A mutant strain of Mycobacterium sp. M 12 was obtained. It can convert cholesterol.3β-acetylcholesterol, sitosterol and 3β-acetyl-sitosterol to 4-androstane-3, 17-dione (4-AD) (mainproduct, the yield is 69%, 70%, 26% and 22% respectively) and 1,4-androstadiene-3,17-dione(ADD) (little amount). Optimum conditions for the side chain cleavage of cholesterol and 3β-acetyl-cholesterol by Mycobawcterium sp. M 12 were studied.
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