Tang Huitong, Ghai Wengang, Zhang Lian, Jing Huirong, Geng Yifang, Fan Lihua, Zhang Qiang , Peng Heping, . ELECTROCHEMICAL REDUCTION OF (R)-1-HYDROXYL-1-(m-HYDROXYLPHENYL)-ACETONE OXIME——A NEW METHOD OF PREPARING METARAMINOLJ. Acta Pharmaceutica Sinica, 1981, 16(6): 440-444.
Citation: Tang Huitong, Ghai Wengang, Zhang Lian, Jing Huirong, Geng Yifang, Fan Lihua, Zhang Qiang , Peng Heping, . ELECTROCHEMICAL REDUCTION OF (R)-1-HYDROXYL-1-(m-HYDROXYLPHENYL)-ACETONE OXIME——A NEW METHOD OF PREPARING METARAMINOLJ. Acta Pharmaceutica Sinica, 1981, 16(6): 440-444.
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ELECTROCHEMICAL REDUCTION OF (R)-1-HYDROXYL-1-(m-HYDROXYLPHENYL)-ACETONE OXIME——A NEW METHOD OF PREPARING METARAMINOL

    Abstract
  • (R)-1-Hydroxyl-1-(m-hydroxylphenyl)-acetone was converted in acidic medium to its oxime (Ⅳ), which was then electrolytically and stereoselectively reduced to give(1R, 2S)-1-(m-hydroxylphenyl)-2-aminopropanol-1, in the same medium. Mercury cathod yielded better result than lead cathod. Polarographic behaviour of the oxime Ⅳ is discussed and reductive cleavage of the hydroxyl group in Ⅳ at the cathod is noted.
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