GUO Hui-yuan, YU Zhi-li, Su Sheng-mao, LIAN Run-mei , ZHANG Zhi-ping, . STUDIES ON PYRIDO (2,3-d) PYRIMIDINE ANTIBACTERIAL AGENTSJ. Acta Pharmaceutica Sinica, 1983, 18(3): 185-190.
Citation: GUO Hui-yuan, YU Zhi-li, Su Sheng-mao, LIAN Run-mei , ZHANG Zhi-ping, . STUDIES ON PYRIDO (2,3-d) PYRIMIDINE ANTIBACTERIAL AGENTSJ. Acta Pharmaceutica Sinica, 1983, 18(3): 185-190.
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STUDIES ON PYRIDO (2,3-d) PYRIMIDINE ANTIBACTERIAL AGENTS

    Abstract
  • The synthesis and antibacterial activity of a series of 2,6-substituted 5,8-dihydro-8-ethyl-5-oxopyrido (2,3-d)pyrimidine are reported. The product from ethyl 2-chloro-4-(2-methoxycarbonyldiethylamino) pyrimidine-5-carboxylate (Ⅳ) through Dieckmann cyclization is determined as methyl 2-chloro-7,8-dihydro-8-ethyl-5-hydroxypyrido (2,3-d) pyrimidine-6-carboxylate (Ⅴ). It exists in the enol form, not the keto form (Ⅵ) as reported by Pesson.
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