STUDIES ON ANTIMICROBIAL AND ANTIVIRAL COMPOUNDS——SYNTHESIS OF DERIVATIVESOF DECANOYL ACETALDEHYDE

Decanoylacetaldehyde (n-Nonyl-β-oxo-aldehyde) is an antibacterial constituent of the Chinese medicinal plant Yü Xing Cao, Houttuynia cordata Thunb), its sodium bisulfite addition compound has been used clinically for the treatment of some infectious diseases. These facts led us to synthesize a number of derivatives of decanoylacetaldehyde in order to obtain more active antimicrobial and antiviral agents. Among them decanoylacetaldehyde bisisonicotinoyl hydrazone(6)showed marked tuberculostatic activity in vitro as well as in vivo, and exhibited definite therapeutic efficacy in primary clinical trial.The derivatives were prepared by condensing methylnonylketone with ethylformate in dry benzene in the presence of sodium, the resulting β-oxo-aldehyde was condensed with corresponding amino compounds to afford the final products.