Preparation and characterization of indomethacin/poly(N-isopropylacrylamide)-β-cyclodextrin complex with temperature-sensitivity

AimTo synthesize poly(N-isopropylacrylamide)/cyclodextrin conjugate (PNIPA-β-CD) as thermosensitive drug carrier, incorporate indomethacin into the conjugate and evaluate the drug release from the carrier in vitro. MethodsPNIPA-β-CD was synthesized by introducing carboxyl terminated PNIPA into the primary hydroxy group of β-CD. The obtained conjugate was characterized by FTIR, ¹H NMR and DSC. The indomethacin/PNIPA-β-CD complex was prepared by lyophilization. In vitro drug release from the complex was carried out at 25 ℃ and 37 ℃ respectively. ResultsThermosensitive PNIPA-β-CD was synthesized successfully. The LCST is 35 ℃, as measured by turbidity method. The drug release from indomethacin/PNIPA-β-CD complex was slower at 37 ℃ than that at 25 ℃. Conclusion Thermosensitive PNIPA-β-CD with molecular inclusion capacity is a potential carrier for drug sustained release.