PREPARATION AND ANTI-HIV ACTIVITY STUDY OF BAICALIEN AND ITS BENZYLATED DERIVATIVES

Baicalein (1) was prepared from baicalin by acid hydrolysis with yield of 24%. 5,6-Dibenzyl-7-hydroxyl-flanone (4) and 6-benzyl-5,7-dihydroxyl flanone (5) were obtained by using different benzylating agents, and then hydrolyzing those benzylated compounds. The total yield of (4) and (5) were 5.9% and 5%, respectively. Both 4 and 5 were less effective than baicalien on inhibition of HIV-1 RT in vitro .