DETERMINATION OF BENORILATE AND ITS IMPURITIES BY RP-HPLC

AIM: To investigate the related substances and determine the contents of benorilate with a new RP HPLC method. METHODS: An ODS column was used. The mobile phase consists of methanol and water (56∶44, pH adjusted to 3.5 with phosphoric acid). The UV detector was set at 240 nm. RESULTS: Benorilate and its related substances paracetamol, acetyl paracetamol, aspirin, salicylic acid and salophen can be separated. The impurities from benorilate products and its preparations were tested and the contents of benorilate were determined. CONCLUSION: The new method can be used to detect the related substances and determine the contents of benorilate.