Q He, YH Xu. SYNTHESIS OF 2β-(4’-METHYL-1’-PIPERAZINO)-3α-HYDROXYL-16,17-SUBSTITUTED-5α-ANDROSTANESJ. Acta Pharmaceutica Sinica, 1992, 27(2): 101-106.
Citation: Q He, YH Xu. SYNTHESIS OF 2β-(4’-METHYL-1’-PIPERAZINO)-3α-HYDROXYL-16,17-SUBSTITUTED-5α-ANDROSTANESJ. Acta Pharmaceutica Sinica, 1992, 27(2): 101-106.
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SYNTHESIS OF 2β-(4’-METHYL-1’-PIPERAZINO)-3α-HYDROXYL-16,17-SUBSTITUTED-5α-ANDROSTANES

    Abstract
  • According to some studies, the vicinal amino-alcohol compounds of 5α- androstane possess to a certain extent biological activities in cardiovascular system. Inorder to find new antiarrhythmic agents, seven new 2β- ( 4'- methyl- 1'- piperazino)-3α- hydroxyl- 16, 17- substituted- 5α- adrostanes were synthesized through 2α,3α- epoxyl-5α-adrostan- 17- one from epiandrosterone. Preliminary results of biologicalexperiment showed that they possess to a different extent antiarrhythmic activities amongwhich compounds VI, XI and XIV showed higher activities than others.
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