S Zeng, L Zhang , ZQ Liu, . QUANTIFICATION OF THE ENANTIOMERS OF OFLOXACIN IN HUMAN URINE BY RP—HPLC WITH CHIRAL MOBILE PHASE ADDITIVEJ. Acta Pharmaceutica Sinica, 1994, 29(3): 223-227.
Citation:
S Zeng, L Zhang , ZQ Liu, . QUANTIFICATION OF THE ENANTIOMERS OF OFLOXACIN IN HUMAN URINE BY RP—HPLC WITH CHIRAL MOBILE PHASE ADDITIVEJ. Acta Pharmaceutica Sinica, 1994, 29(3): 223-227.
S Zeng, L Zhang , ZQ Liu, . QUANTIFICATION OF THE ENANTIOMERS OF OFLOXACIN IN HUMAN URINE BY RP—HPLC WITH CHIRAL MOBILE PHASE ADDITIVEJ. Acta Pharmaceutica Sinica, 1994, 29(3): 223-227.
Citation:
S Zeng, L Zhang , ZQ Liu, . QUANTIFICATION OF THE ENANTIOMERS OF OFLOXACIN IN HUMAN URINE BY RP—HPLC WITH CHIRAL MOBILE PHASE ADDITIVEJ. Acta Pharmaceutica Sinica, 1994, 29(3): 223-227.
QUANTIFICATION OF THE ENANTIOMERS OF OFLOXACIN IN HUMAN URINE BY RP—HPLC WITH CHIRAL MOBILE PHASE ADDITIVE
The method for determination of S-(-)and R- (+)- ofloxacim(OFLX)in humanutine by RP-HPLC with a chiral mobile phase additive is described.L-phenylalanine was used as thechiral additive,Cu2+ as the ligand ion and fluorescence for detection,This chiral ligand exchangechromatography has been applied to reveal the enantioselective disposition of ofloxacin in humanvolunteers.
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