Synthesis and antioxidative activity of 2-substituted phenyl-5-(3′-indolyl)-oxazole derivatives

AimTo study the synthesis of 5-(3′-indolyl)-oxazoles and their antioxidative activity. MethodsThe amides were prepared from tryptophan and different acid derivatives by the catalytic dehydration of dicyclohexyl carbodiimide (DCC). The characteristic heterocyclic ring system of 5-(3′-indolyl)-oxazoles was constructed by oxidative cyclization of amide, using dicholorodicyanoquinone (DDQ). Their antioxidative activity in vitro was tested using DPPH system. ResultsEleven 2-substituted phenyl-5-(3′-indolyl)-oxazoles were prepared, the compounds 21 and 22 have shown antioxidative activity 3-4 times stronger than that of Vit E, and the compound 29 showed antioxidative activity almost as same as Vit E. ConclusionThree 5-(3′-indoyl)-oxazole compounds synthesized showed potent antioxidative effect and they would be a good antioxidants.