STUDIES ON THE CHEMICAL CONSTITUENTS OF TRIPTERYGIUM WILFORDII HOOK.F. Ⅲ. THE ISOLATION AND STRUCTURE OF TWO NEW DITERPENOID-LACTONES, TRIPTOPHENOLIDE METHYL ETHER AND NEOTRIPTOPHENOLIDE

In a previous paper (1) the isolation of triptolide, tripdiolide and triptonolide from Tripterygium wilfordii Hook. f. was reported. This paper reports the isolation of three other diterpenoid-lactones: (1) triptophenolide, C₂₀H₂₄O₃, mp 232～233℃; (2) triptophenolide methyl ether, C₂₁H₂₆O₃, mp 152～154℃, and (3) neotriptophenolide, C₂₁H₂₆O₄, mp 189～191℃. Their structures are assigned as Ⅴ, Ⅵ and Ⅶ, respectively, by spectroscopic analysis (UV, IR, MS, ¹HNMR and ¹³CNMR) and preparation of their derivatives. It has beert shown that Ⅵ and Ⅶ are new diterpenoid compounds.