STUDIES ON THE ANTIPYRETIC AND ANALGESIC ACTIONS OF ACTINODAPHNINE

In this paper, the antipyretic and analgesic actions of actinodaphnine, isolated from Illigera SP, were studied. The results are as follows: 1. The normal body-temperature in mice, rats or rabbits was reduced by actinoaphnine ip; 2. The fever induced by colibacillus and peptone in rabbits was also markedly reduced by actinodphnine ip; 3. The writhing response in mice was inhibited and the pain threshold was markedly elevated by actinodaphnine ip; But the effect of actinodaphnine on the pain threshold in mice (i. c. v) was not obvious.These results indicate that: actinodaphnine had antipyretic and analgesic actions. The antipyretic action of actinodaphnine was recognized as increasing the loss of heat from the body-surface. The analgesic action (hot plate method) of actinodaphnine appears to be not of central nature, but related to reduction of the skin temperature of the palm of mice or to the production of local anesthesia.