STUDY ON THE DETERMINATION OF ZINC IN PLASMA AFTER ORAL ADMINISTRATION OF LICORZIN BY ATOMIC ABSORPTION SPECTROPHOTOMETRY AND THE PHARMACOKINETICS OF ZINC IN HEALTHY VOLUNTEERS

A rapid, accurate and sensitive atomic absorption spectrophotometry was established for the determination of zinc in plasma after oral administration of licorzin to healthy volunteers. The plasma sample diluted with de-ionized water (1:1) was determined directly. A 5% glycerol solution was used as the solvent of zinc standard solution. The recovery of the proposed method was 97.3±4.3%. The precisions(CV%) of within-day and dayto-day were less than 5%. The pharmacokinetics of zinc in healthy volunteers after oral administration of 2.5 g licorzin was studied. The results showed that an one-compartment model (K_a=K) was found in 10 healthy volunteers. The pharmacokinetic parameters were as follows:K_a=K=0.380h^-1, T_max=2.7h, V=33.03 L, T_1/2=1.9h.