COMPLEXOMETRIC TITRATION IN THE DETERMINATION OF ALKALOIDS Ⅰ. THE DETERMINATION OF ALKALOID SALTS BY CATION-EXCHANGE FOLLOWED BY COMPLEXOMETRIC TITRATION

The determination is carried out by passing a solution of an alkaloid salt through a 0.5×16cm column of cation-exchange resin in the Cu-form. The Cu⁺⁺ liberated is washed out with 40ml of H₂O and titrated with 0.005 or 0.0025 M EDTA·2Na using murexide as indicator. For 10—20mg samples of the hydrochlorides of ephedrine, procaine, thiamine, pyridoxine, aureomycin, and the sulfates of atropine, strychnine, and quinine, the error is 2—0.5%.