EFFECTS OF LEUKOTRIENES ON PRODUCTION OF INTERLEUKIN 6 FROM MOUSE PERITONEAL MACROPHAGES

In the present study, effects of leukotrienes on IL-6 production by mouse resident peritoneal macrophages were explored with a bioassay method involving IL-6 dependent murine hybridoma B9 cell line. The results showed that LTB₄, LTC₄ and LTD₄ can enhance the production of IL-6 from cultured peritoneal macrophages of mice. The optimal concentractions for LTB₄, LTC₄ and LTD₄ were found to be 1.45×10^-6, 6.9×10^-8 and 8.05×10^-8 mol·L^-1, respectively. The results suggest that peptide leukotrienes might play important role on IL-6 production in the local milieu of inflammation.