GUO Zheng-Ming, WAN Feng, GU Zhi-Ping, WU Guo-Pei , PENG Si-Xun, . SYNTHESIS OF MONO-ALDEHYDE GOSSYPOL AND ITS ANALOGUESJ. Acta Pharmaceutica Sinica, 1987, 22(8): 597-602.
Citation: GUO Zheng-Ming, WAN Feng, GU Zhi-Ping, WU Guo-Pei , PENG Si-Xun, . SYNTHESIS OF MONO-ALDEHYDE GOSSYPOL AND ITS ANALOGUESJ. Acta Pharmaceutica Sinica, 1987, 22(8): 597-602.
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SYNTHESIS OF MONO-ALDEHYDE GOSSYPOL AND ITS ANALOGUES

    Abstract
  • In an attempt to keep the antispermatogenic activity but lower the toxicity of gossypol by way of structural modification, mono-aldehyde gossypol and four other gossypol analogues have been synthesized. The test of spermicidal activity of these compounds in vitro in 20 seconds showed that mono-aldehyde gossvpol, compound 3, is better than gossvnol.
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