Yin Zhihua, Zhang Liqing , Zhou Weishan, . MICROBIOLOGICAL DEHYDROGENATION OF 3′-(5α, 3β, 17β-DIHYDROXY-ANDRASTANE-17α)-PROPIOLACTONE (V) BY NOCARDIA SP -SYNTHESIS OF SPIROLACTONE(Ⅱ)J. Acta Pharmaceutica Sinica, 1980, 15(12): 730-735.
Citation: Yin Zhihua, Zhang Liqing , Zhou Weishan, . MICROBIOLOGICAL DEHYDROGENATION OF 3′-(5α, 3β, 17β-DIHYDROXY-ANDRASTANE-17α)-PROPIOLACTONE (V) BY NOCARDIA SP -SYNTHESIS OF SPIROLACTONE(Ⅱ)J. Acta Pharmaceutica Sinica, 1980, 15(12): 730-735.
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MICROBIOLOGICAL DEHYDROGENATION OF 3′-(5α, 3β, 17β-DIHYDROXY-ANDRASTANE-17α)-PROPIOLACTONE (V) BY NOCARDIA SP -SYNTHESIS OF SPIROLACTONE(Ⅱ)

    Abstract
  • Incubation of 3'-(5α, 3β, 17β-dihydroxy-androstane-17α)-Propiolactone (Ⅴ) with Nocardia sp. afforded 6 compounds (Ⅱ and Ⅵ～Ⅹ), among which spirolactone (Ⅱ) was. the major product (～50%). Ⅷ～Ⅹ were unidentified hydroxy compounds. The △4-3-keto compound (Ⅱ) is the main product when the medium is poor in nitrogen.
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