GQ Zeng, DW Ju, DX Sun, YC Rui. EFFECTS OF DAURICINE AND ANISODAMINE ON LTs AND PAF INDUCED DNA SYNTHESIS IN BOVINE ANTERIOR CEREBRAL ARTERIAL SMOOTH MUSCLE CELLSJ. Acta Pharmaceutica Sinica, 1992, 27(8): 561-565.
Citation: GQ Zeng, DW Ju, DX Sun, YC Rui. EFFECTS OF DAURICINE AND ANISODAMINE ON LTs AND PAF INDUCED DNA SYNTHESIS IN BOVINE ANTERIOR CEREBRAL ARTERIAL SMOOTH MUSCLE CELLSJ. Acta Pharmaceutica Sinica, 1992, 27(8): 561-565.
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EFFECTS OF DAURICINE AND ANISODAMINE ON LTs AND PAF INDUCED DNA SYNTHESIS IN BOVINE ANTERIOR CEREBRAL ARTERIAL SMOOTH MUSCLE CELLS

    Abstract
  • The effects of leukotrienes (LTs) and platelet activating factor (PAF)on DNA synthesis in bovine anterior cerebral arterial smooth muscle cells were studied. Theresults showed that LTB4, LTD4 and PAF were all stimulatory to the cells. The maximalrates of stimulation were 32%, 29% and 77%, respectively, for LTB4, LTD4 and PAF at10-7 mol/L. Both dauricine and anisodamine at concentrations of 10-7 to 10-4 mol/L ex-hibited strong inhibitory effects on LTs and PAF induced DNA synthesis.
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