THE SYNTHESIS AND BIOACTIVITIES OF CHOLINERGIC TROPANE ALKALOIDS

Ten analogs of baogongteng A, the natural cholinergic tropane alkaloid isolated from Erycibe obtusifolia Benth, were designed and synthesized. The tropane skeleton was kept unchanged, while the substituting groups on N and C₃ were modified. In myotic experiments in rabbits 3-paramethyl benzoyloxy- 6-acetoxy nortropane (4), 3-propionyloxy- 6-acetoxy nortropane (5), and 3-isobutyryloxy-6-acetoxy nortropane(6) showed cholinergic activities.