KUMUJANSINE AND KUMUJANTINE, TWO NEW DIMERIC β-CARBOLINE ALKALOIDS FROM PICRASMA QUASSIOIDES (D.DON.) BENN.

Two new dimeric β-carboline alkaloids, named kumujansine and kumujantine, were isolated from an alcohol extract of the heartwood of Picrasma quassioides (D. Don.) Benn. (Simaroubaceae) by silica gel and alumina column chromatography.Kumujansine hydrochloride was obtained as light yellow granulous crystal, mp 249～250℃ (dec). Its molecular formula is C₂₈H₂₅N₄O₂Cl. Based on spectral (UV, IR, ¹H-NMR, ¹H-¹H cosy spectrum and ¹³C-NMR as well as MS) analysis its structure was elucidated as (Ⅰ).Kumujantine hydrochloride is also a light yellow granulous crystal, mp 270℃ (dec). Its molecular formula is C₃₀H₂₉N₄O₄ Cl. Based on analysis of spectral data its structure was identified as (Ⅱ).