LI Ji-cheng, LIU Chen-jiang, AN Xin-zong, WANG, Mao-tian, ZHAO Tian-zeng, YU Shou-zhi, ZHAO Gen-suo , CHEN Rong-feng. STUDIES ON THE ANTITUMOR CONSTITUENT OF RABDOSIA JAPONICA (BURM. F) HARA. THE STRUCTURES OF RABDOSIN A AND BJ. Acta Pharmaceutica Sinica, 1982, 17(9): 682-687.
Citation: LI Ji-cheng, LIU Chen-jiang, AN Xin-zong, WANG, Mao-tian, ZHAO Tian-zeng, YU Shou-zhi, ZHAO Gen-suo , CHEN Rong-feng. STUDIES ON THE ANTITUMOR CONSTITUENT OF RABDOSIA JAPONICA (BURM. F) HARA. THE STRUCTURES OF RABDOSIN A AND BJ. Acta Pharmaceutica Sinica, 1982, 17(9): 682-687.
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STUDIES ON THE ANTITUMOR CONSTITUENT OF RABDOSIA JAPONICA (BURM. F) HARA. THE STRUCTURES OF RABDOSIN A AND B

    Abstract
  • Four diterpenoids were isolated from the dried leaves of Rabdosia japonica (Burm.f) Hara. Two new diterpenoids were named as rabdosin A and B. Spectroscopic investigation and chemical conversion into epinodosin(6) and isodonal(8) established the structures of rabdosin A and B as(3) and(7)respectively. Antitumor activity has been tested preliminarily, both (3) and (7) showed significant cytotoxicity. The other two diterpenoids were shown to be identical with the known enmenol (4) and peinodosinol(5).
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